Analytical Data
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基因名
PKCE
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简介
PKCE proteins are calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine protein kinases. PKCE Protein, Human (His) is the recombinant human-derived PKCE protein, expressed by E. coli , with C-6*His labeled tag.
- Application
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别名
Protein Kinase C Epsilon Type; nPKC-Epsilon; PRKCE; PKCE
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种属
Human
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表达系统
E. coli
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标签
C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q02156
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表达区间
Q580-P737
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蛋白长度
Partial
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分子量
20 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PKCE, or protein kinase C epsilon, is a member of the protein kinase C (PKC) family, which plays a critical role in various cellular processes, including growth, differentiation, and apoptosis. Research on PKCE has garnered significant attention due to its involvement in several pathophysiological conditions, notably cancer, cardiovascular diseases, and neurodegenerative disorders. The dysregulation of PKCE activity has been linked to tumor growth and metastasis, making it a potential biomarker and therapeutic target in oncology. Furthermore, its modulatory effects on signaling pathways have sparked interest in its role in heart disease and its neuroprotective properties. This has led to the exploration of PKCE as a target for drug development, aiming to harness its potential in therapeutic interventions. Advances in molecular biology and structural biology have facilitated the understanding of PKCE's structure and function, paving the way for the development of selective inhibitors or activators. Researchers are also investigating PKCE's role in specific cellular signaling networks, aiming to delineate its mechanisms of action further. Overall, the study of PKCE and its reassembled proteins represents a promising frontier in biomedical research, with the potential to contribute significantly to the development of novel therapies for various diseases.
