Analytical Data
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Gene name
EXOSC5
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简介
EXOSC5 is a non-catalytic RNA exosome complex component that is critical in 3'->5' exoribonuclease activity and affects a variety of cellular RNA processing and degradation processes. In the nucleus, it contributes to stable RNA maturation, byproduct elimination, and noncoding transcript degradation. EXOSC5 Protein, Human (His, Strep) is the recombinant human-derived EXOSC5 protein, expressed by E. coli , with N-Strep, N-6*His labeled tag.
- Application
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Alternative Names
EXOSC5; Exosome complex component RRP46; Chronic myelogenous leukemia tumor antigen 28; Exosome component 5; Ribosomal RNA-processing protein 46; p12B
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Species
Human
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Source
E. coli
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Tag
N-StrepⅡ;N-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NQT4
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Expression Region
M1-S235
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Protein Length
Full Length
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EXOSC5, a crucial component of the exosome complex, plays a significant role in RNA processing and degradation within the cell. This multi-protein complex is involved in the regulation of various cellular processes, including gene expression, mRNA turnover, and the maintenance of RNA quality control. Dysregulation of EXOSC5 has been linked to several human diseases, including neurodegenerative disorders and cancer, highlighting its importance in cellular homeostasis. Research on recombinant EXOSC5 proteins aims to elucidate its structure-function relationships and the mechanisms by which it interacts with other exosome components and RNA substrates. By generating and characterizing recombinant EXOSC5, scientists seek to uncover its specific roles in RNA metabolism and its potential as a therapeutic target. The study of EXOSC5 also provides insights into the general principles of exosomal RNA regulation, which is critical for understanding how cells respond to various stresses and how they regulate the fate of their RNA molecules. As such, recombinant EXOSC5 is a valuable tool for advancing our understanding of RNA biology and developing novel strategies for disease intervention.
