Analytical Data
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基因名
EXOSC8
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简介
EXOSC8 is a non-catalytic RNA exosome complex component that is critical for 3'->5' exoribonuclease activity and affects a variety of cellular RNA processing and degradation. In the nucleus, it helps stabilize the maturation of RNA species and eliminates processing by-products, non-coding transcripts and defective mRNAs, thereby preventing their export to the cytoplasm. EXOSC8 Protein, Human (His, Strep) is the recombinant human-derived EXOSC8 protein, expressed by E. coli , with N-Strep, N-6*His labeled tag.
- Application
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别名
EXOSC8; Exosome complex component RRP43; Exosome component 8; Opa-interacting protein 2; OIP-2; Ribosomal RNA-processing protein 43; p9
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种属
Human
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表达系统
E. coli
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标签
N-StrepⅡ;N-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96B26
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表达区间
M1-K276
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蛋白长度
Full Length
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EXOSC8, a pivotal component of the exosome complex, is involved in RNA degradation and processing, playing a crucial role in maintaining cellular RNA homeostasis. Research surrounding EXOSC8 has gained importance due to its implications in various cellular processes, including the regulation of gene expression and responses to stress. Mutations in the EXOSC8 gene have been associated with the rare genetic disorder schwachman-diamond syndrome, which is characterized by bone marrow failure, pancreatic insufficiency, and skeletal abnormalities. Understanding the structure and function of EXOSC8 through recombinant protein studies can illuminate its role in RNA metabolism and the pathophysiology of related diseases. By employing techniques such as protein expression, purification, and functional assays, researchers aim to dissect the biochemical properties of EXOSC8, assess its interaction with other exosome components, and explore how its dysfunction leads to disease phenotypes. Ultimately, investigations into EXOSC8 recombinant protein could not only augment our understanding of basic cellular processes but also pave the way for novel therapeutic strategies targeting the molecular underpinnings of RNA degradation and related disorders.
