Recombinant Escherichia coli MCR-1 Protein，His & SUMO

MCR-1 (Mobile Colistin Resistance-1) is a gene that confers resistance to colistin, an antibiotic often used as a last resort for treating multi-drug resistant infections, particularly those caused by Gram-negative bacteria. Discovered in 2015, MCR-1 raised significant global health concerns as it is located on plasmids, allowing its rapid dissemination among various bacterial species. The emergence of MCR-1 indicates a worrying trend toward the increasing prevalence of antibiotic resistance, complicating treatment protocols and threatening effective infection control. Researchers have focused on this resistance mechanism to understand its genetic basis, transmission dynamics, and its potential impact on public health. Investigating MCR-1 also involves studying its interaction with other resistance genes and the overall resistance patterns in bacterial populations. Moreover, efforts are being made to devise new antimicrobial strategies to combat MCR-1 carrying organisms and to monitor the spread of this gene in clinical and environmental settings. The urgency of this research is underscored by the rising incidence of infections caused by resistant pathogens, necessitating comprehensive surveillance and innovative therapeutic approaches to safeguard public health against the growing threat of antimicrobial resistance.