Analytical Data
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Gene name
CHI3L1
- Application
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Alternative Names
GP39; CHI3-L1; YKL40; Chondrex; Chitinase 3-Like 1; Chondrocyte Protein YKL40; 39 kDa synovial protein
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
P36222
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Expression Region
Asn112~Thr237+Ile299~Lys377
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Molecular Weight
26kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CHI3L1, also known as chitinase 3-like 1 or YKL-40, is a glycoprotein that has garnered significant attention in recent years due to its involvement in various pathological processes, particularly in inflammation and tissue remodeling. This protein is primarily expressed in macrophages, chondrocytes, and other cell types in response to pro-inflammatory stimuli. Elevated levels of CHI3L1 have been implicated in different diseases, including cancer, asthma, and autoimmune disorders, where it often serves as a biomarker for disease progression and severity. Research has suggested that CHI3L1 plays a crucial role in modulating inflammation and has potential implications for therapeutic intervention. The protein's ability to bind to chitin and its structural similarities to chitinases suggest that it may influence extracellular matrix dynamics and tissue repair processes. Consequently, recombinant CHI3L1 has emerged as a valuable tool for studying its biological functions, mechanisms of action, and potential clinical applications. Understanding the role of CHI3L1 in various diseases could lead to novel therapeutic strategies and improve diagnostic capabilities in inflammatory and degenerative conditions. The ongoing exploration of its multifaceted roles highlights the significance of CHI3L1 as a target for both research and clinical advancements.
