Analytical Data
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Gene name
ATXN3L
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简介
The ATXN3L protein is a deubiquitinating enzyme that exhibits multiple activities by cleaving “Lys-48”-linked and “Lys-63”-linked polyubiquitin chains in vitro. It functions as a specific deubiquitinase for the transcription factor KLF5 and contributes to the stability regulation of KLF5. ATXN3L Protein, Human (sf9, His, FLAG) is the recombinant human-derived ATXN3L protein, expressed by sf9 insect cells , with C-Flag, N-8*His labeled tag.
- Application
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Alternative Names
ATXN3L; Ataxin-3-like protein; Machado-Joseph disease protein 1-like
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Species
Human
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Source
Baculovirus
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Tag
C-Flag;N-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H3M9
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Expression Region
D2-K355
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ATXN3L (Ataxin-3-like protein) is a member of the ataxin-3 family, which is characterized by a Josephin domain and a polyglutamine (polyQ) tract. This protein has gained attention in recent years due to its structural similarity to ATXN3, a protein associated with Machado-Joseph disease, a neurodegenerative disorder. While ATXN3 is well-studied for its role in ubiquitin-proteasome pathways and its involvement in neurodegeneration, ATXN3L remains less explored. Preliminary studies suggest that ATXN3L may play a role in cellular stress responses and protein degradation, potentially influencing neuroprotective mechanisms. Researchers are particularly interested in understanding the functional significance of the unique features of ATXN3L, including its diverse interaction partners and potential regulatory functions in cellular homeostasis. Investigating the biochemical properties, expression patterns, and functional implications of ATXN3L may provide insights into its biological roles and open avenues for therapeutic strategies in neurodegenerative diseases. As the understanding of ATXN3L continues to evolve, it holds promise for elucidating new pathways involved in neuronal health and unraveling the complexities of similar neurodegenerative conditions.
