Analytical Data
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Gene name
USP46
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简介
USP46 protein, as a deubiquitinating enzyme, may participate in behavioral regulation by regulating the effects of GABA. Suggested to mediate deubiquitination of GAD1/GAD67, affecting processes related to GABAergic neurotransmission. USP46 Protein, Human (His, GST) is the recombinant human-derived USP46 protein, expressed by E. coli , with N-6*His, N-GST labeled tag.
- Application
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Alternative Names
USP46; Ubiquitin carboxyl-terminal hydrolase 46; Deubiquitinating enzyme 46; Ubiquitin thioesterase 46; Ubiquitin-specific-processing protease 46
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Species
Human
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Source
E. coli
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Tag
N-6*His;N-GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P62068
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Expression Region
M1-E366
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Protein Length
Full Length
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
USP46 (Ubiquitin Specific Peptidase 46) is a deubiquitinating enzyme that plays a crucial role in protein homeostasis and cellular signaling by removing ubiquitin moieties from target proteins, thus regulating their stability and function. Recent studies have highlighted its significance in various biological processes, including neurodevelopment, apoptosis, and immune response. Dysregulation of USP46 has been linked to several diseases, including neurodegenerative disorders and cancer. Given its importance, researchers have focused on understanding the structural and functional mechanisms of USP46, exploring its substrate specificity and interactions with other cellular components. Structural characterization of USP46 through techniques like X-ray crystallography and NMR has provided insights into its enzymatic activity and regulatory mechanisms, which could pave the way for the development of novel therapeutics targeting this enzyme. Furthermore, the potential of USP46 as a biomarker for certain diseases is being investigated, emphasizing its relevance in clinical research. As such, ongoing studies aim to elucidate the comprehensive role of USP46 in cellular biology, aiming to harness its therapeutic potential in combating diseases associated with aberrant ubiquitin signaling.
