Analytical Data
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Gene name
Stratifin
- Application
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Alternative Names
YWHAS; HME1; 14-3-3 Protein Sigma; Epithelial cell marker protein 1
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
P31947
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Expression Region
Met1~Ser248
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Molecular Weight
29kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Stratifin, also known as SFN or 14-3-3 sigma, is a member of the 14-3-3 protein family that plays a crucial role in various cellular processes, including cell cycle regulation, apoptosis, and stress response. Research on Stratifin has gained prominence due to its significant implications in cancer biology and its potential as a biomarker for various malignancies. In normal tissues, Stratifin is involved in the regulation of cell proliferation and differentiation, acting as a tumor suppressor. However, its expression is often downregulated or lost in several types of tumors, contributing to uncontrolled cell growth and tumor progression. Understanding the mechanisms governing Stratifin's function and its interactions with other molecular pathways is essential for elucidating its role in tumorigenesis. Recent studies have focused on the recombinant production of Stratifin to investigate its structural and functional properties, providing insights into its biological activity. These recombinant proteins enable detailed studies of Stratifin's interactions with other cellular proteins, offering potential avenues for therapeutic intervention in cancer treatment. The exploration of Stratifin's role in cellular signaling and its potential use as a therapeutic target highlights the need for continued research in this area, which could pave the way for novel approaches in cancer diagnostics and treatment strategies.
