Analytical Data
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Gene name
IL-1R3/IL-1 RAcP
- Application
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Alternative Names
IL1RAP
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Species
Cynomolgus
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Source
HEK293
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Tag
C-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
G7NYP7
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Expression Region
S21-C362
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Protein Length
Partial
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Molecular Weight
55-70 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Interleukin-1 receptor-like protein 3 (IL-1R3), also known as interleukin-1 receptor accessory protein (IL-1RAcP), plays a critical role in the signaling pathways of the interleukin-1 (IL-1) family, which are vital for immune responses and inflammation. This protein functions as a co-receptor for IL-1 cytokines, enhancing the biological activities of IL-1 agonists by forming a functional receptor complex, thereby facilitating downstream signaling through the MyD88-dependent pathway. Increased expression of IL-1R3/IL-1RAcP has been implicated in various pathological conditions, including autoimmune diseases and cancer, making it a target of interest for therapeutic interventions. Understanding the structure and function of this receptor is crucial for developing specific inhibitors that could modulate its activity in inflammatory conditions. Research on IL-1R3/IL-1RAcP recombinant proteins aims to elucidate its role in cellular signaling, characterize its interaction with IL-1 ligands, and explore its potential implications in disease. The production of recombinant IL-1R3/IL-1RAcP facilitates in-depth studies of its functional properties, opening avenues for novel drug development strategies aimed at inflammatory diseases.
