Analytical Data
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基因名
FAK1
- Application
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别名
PTK2; FADK; FAK1; Pp125FAK; PPP1R71; Protein Tyrosine Kinase 2; Focal adhesion kinase-related nonkinase; Protein phosphatase 1 regulatory subunit 71
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
Q05397
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表达区间
Gly798~Ala1041
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分子量
33kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FAK1 (Focal Adhesion Kinase 1) is a non-receptor protein tyrosine kinase critically involved in cellular processes such as proliferation, survival, migration, and differentiation. Its role in mediating integrin signaling at focal adhesions links the extracellular matrix to the cytoskeleton, thereby influencing cellular responses to their environment. Dysregulation of FAK1 has been implicated in various diseases, including cancer, where its overexpression is often associated with increased tumor progression and metastasis. Consequently, FAK1 has emerged as a promising therapeutic target in oncology. Researchers have been focusing on the development of recombinant FAK1 proteins to better understand its structural and functional characteristics, allowing for insights into its regulatory mechanisms. Such studies aim to elucidate how FAK1 interacts with other proteins and pathways, providing a foundation for potential drug design. Moreover, structural analysis of FAK1 can unveil conformational changes upon ligand binding, which is essential for understanding its activation and subsequent signaling cascades. Overall, further investigation into the recombinant expression and functional characterization of FAK1 is essential for developing innovative strategies to mitigate diseases associated with its aberrant activity.
