Analytical Data
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Gene name
PHLPP2
- Application
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Alternative Names
KIAA0931; PHLPPL
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Species
Human
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Source
E. coli
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Tag
GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6ZVD8-1
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Expression Region
K766-E1043
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PHLPP2 (PH domain and leucine-rich repeat protein phosphatase 2) is a member of the PHLPP family of phosphatases, which play critical roles in cellular signaling by dephosphorylating key proteins involved in various physiological processes. The research surrounding PHLPP2 has gained traction due to its involvement in regulating Akt signaling pathways, which are crucial for cell growth, survival, and metabolism. Aberrant activation of Akt is commonly associated with various cancers and metabolic disorders, highlighting the therapeutic potential of targeting phosphatases like PHLPP2. Moreover, studies have suggested that PHLPP2 may have implications in cardiovascular diseases and neurodegenerative conditions, making it a protein of interest for understanding diverse disease mechanisms. By producing and characterizing recombinant PHLPP2, researchers aim to elucidate its biological functions and regulatory mechanisms, which may lead to the development of novel therapeutic strategies. Additionally, investigating the effects of PHLPP2 on various substrates and signaling pathways could provide insights into its role in tumor suppression and cellular homeostasis. Overall, the study of recombinant PHLPP2 represents a promising avenue for advancing our understanding of phosphatase biology and its potential applications in disease treatment.
