Analytical Data
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基因名
VCPIP1
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简介
The VCPIP1 protein is a multifunctional deubiquitinating enzyme that plays a crucial role in a variety of cellular processes. It is an integral component of DNA repair and postmitotic Golgi and endoplasmic reticulum reassembly, promoting VCP-mediated Golgi stacking and tER formation. VCPIP1 Protein, Human (sf9) is the recombinant human-derived VCPIP1 protein, expressed by sf9 insect cells , with tag free.
- Application
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别名
VCPIP1; Deubiquitinating protein VCPIP1; Valosin-containing protein p97/p47 complex-interacting protein 1; Valosin-containing protein p97/p47 complex-interacting protein p135; VCP/p47 complex-interacting 135-kDa protein
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种属
Human
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表达系统
Baculovirus
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96JH7
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表达区间
M1-S1222
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蛋白长度
Full Length
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
VCPIP1 (Valosin-containing protein intercistronic protein 1) is a crucial regulatory protein involved in multiple cellular processes, including protein degradation, cell cycle regulation, and DNA repair. Its role as a deubiquitinating enzyme emphasizes its importance in modulating the protein degradation pathway, particularly in the context of proteasomal degradation. Dysregulation of VCPIP1 has been implicated in various diseases, including cancer and neurodegenerative disorders, making it a target of interest for therapeutic interventions. Recent studies have shown that VCPIP1 interacts with key proteins involved in the ubiquitin-proteasome system, influencing cellular homeostasis and stress responses. The generation of recombinant VCPIP1 protein provides an invaluable tool for understanding its biochemical properties and functional mechanisms. By producing VCPIP1 in a controlled laboratory setting, researchers can examine its enzymatic activity, binding interactions, and regulatory dynamics in detail. This knowledge is essential for elucidating the pathways through which VCPIP1 operates and its potential role as a biomarker or therapeutic target in disease contexts. Furthermore, exploring the structural aspects of VCPIP1 through recombinant techniques may reveal insights into its regulation and interaction networks, ultimately contributing to advancements in drug discovery and the development of targeted therapies for diseases linked to VCPIP1 dysfunction.
