Analytical Data
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基因名
HADHB
- Application
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别名
TP-beta （Acetyl-CoA acyltransferase）（Beta-ketothiolase）
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种属
Mouse
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表达系统
E. coli
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标签
N- His & C- Myc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q99JY0
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表达区间
35-475aa
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分子量
54.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HADHB, or Hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase multienzyme complex, plays a critical role in fatty acid catabolism and mitochondrial energy production. Mutations in the HADHB gene can lead to a rare metabolic disorder known as mitochondrial acyl-CoA dehydrogenase deficiency, associated with severe clinical manifestations, including hypoglycemia, cardiomyopathy, and neurological impairments. Research into HADHB recombinant proteins has become increasingly important as scientists aim to understand the enzyme's structure-function relationship and its regulation within metabolic pathways. Producing recombinant HADHB proteins allows for in-depth biochemical studies, such as enzyme kinetics, substrate specificity, and interaction with other metabolic enzymes. Additionally, these studies may provide insights into the molecular mechanisms underlying HADHB-related metabolic disorders, paving the way for potential therapeutic strategies. As the prevalence of metabolic diseases continues to rise globally, understanding the intricacies of HADHB enforces the relevance of this research in developing effective diagnostics and treatments, thereby improving patient care in affected individuals.
