Analytical Data
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基因名
SENP8
- Application
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别名
Deneddylase-1NEDD8-specific protease 1;Protease, cysteine 2Sentrin/SUMO-specific protease SENP8
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种属
Human
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96LD8
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表达区间
1-212aa
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分子量
40.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SENP8, a member of the Sentrin/SUMO-specific protease (SENP) family, plays a critical role in the regulation of SUMOylation, a post-translational modification that influences various cellular processes including protein stability, localization, and activity. This protease facilitates the maturation and deconjugation of SUMO peptides from target proteins, thus modulating their functions. The dysregulation of SUMOylation has been implicated in several diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. Research into SENP8 is particularly significant as it has been shown to have a role in cell proliferation and apoptosis, suggesting that it may contribute to tumor progression and metastasis. Understanding the structure and function of SENP8 can provide insights into its potential as a therapeutic target. Recent studies have focused on the purification and characterization of recombinant SENP8 to investigate its enzymatic activity and substrate specificity. These recombinant proteins are crucial for elucidating the underlying mechanisms of SENP8 in cellular pathways and developing inhibitors that could modulate its activity for therapeutic applications. By delineating the biochemical properties of SENP8 and its interaction with SUMO substrates, researchers aim to gain a deeper understanding of its potential roles in health and disease, laying the groundwork for novel treatment strategies.
