Analytical Data
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Gene name
SENP8
- Application
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Alternative Names
Deneddylase-1NEDD8-specific protease 1;Protease, cysteine 2Sentrin/SUMO-specific protease SENP8
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Species
Human
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96LD8
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Expression Region
1-212aa
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Molecular Weight
40.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SENP8, a member of the Sentrin/SUMO-specific protease (SENP) family, plays a critical role in the regulation of SUMOylation, a post-translational modification that influences various cellular processes including protein stability, localization, and activity. This protease facilitates the maturation and deconjugation of SUMO peptides from target proteins, thus modulating their functions. The dysregulation of SUMOylation has been implicated in several diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. Research into SENP8 is particularly significant as it has been shown to have a role in cell proliferation and apoptosis, suggesting that it may contribute to tumor progression and metastasis. Understanding the structure and function of SENP8 can provide insights into its potential as a therapeutic target. Recent studies have focused on the purification and characterization of recombinant SENP8 to investigate its enzymatic activity and substrate specificity. These recombinant proteins are crucial for elucidating the underlying mechanisms of SENP8 in cellular pathways and developing inhibitors that could modulate its activity for therapeutic applications. By delineating the biochemical properties of SENP8 and its interaction with SUMO substrates, researchers aim to gain a deeper understanding of its potential roles in health and disease, laying the groundwork for novel treatment strategies.
