Analytical Data
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Gene name
SENP7
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简介
SENP7, a versatile protease, positively regulates the cGAS-STING pathway by desumoylating CGAS, enhancing its DNA-binding and activation. Specific to SUMO2 and SUMO3, SENP7 proficiently deconjugates poly-SUMO2 and poly-SUMO3 chains, dynamically regulating protein sumoylation. While less efficient in processing full-length SUMO proteins, SENP7's role in modulating the cGAS-STING pathway highlights its importance in innate immune responses. SENP7 Protein, Human is the recombinant human-derived SENP7 protein, expressed by E. coli , with tag free.
- Application
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Alternative Names
Sentrin-Specific Protease 7; SUMO-1-Specific Protease 2; Sentrin/SUMO-Specific Protease SENP7; SENP7; KIAA1707; SSP2; SUSP2
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Species
Human
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Source
E. coli
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BQF6-1
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Expression Region
M695-A864
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Protein Length
Partial
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Molecular Weight
22 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SENP7, a member of the Sentrin/SUMO-specific protease (SENP) family, plays a crucial role in the regulation of the SUMO (Small Ubiquitin-like Modifier) modification pathway, which is vital for various cellular processes including transcription, DNA repair, and stress responses. Unlike other SENPs, SENP7 exhibits unique substrate specificity and is known to remove SUMO chains from specific target proteins, thereby influencing their stability and activity. The dysregulation of SENP7 has been linked to several pathological conditions, including cancer and neurodegenerative diseases, making it a potential therapeutic target. Research on recombinant SENP7 protein is essential for understanding its biochemical properties, enzymatic functions, and interaction with SUMO-conjugated substrates. By producing and purifying recombinant SENP7 in a controlled laboratory setting, scientists aim to elucidate its structural characteristics and catalytic mechanisms. Furthermore, the study of recombinant SENP7 is critical in developing high-throughput screening assays to identify small molecule inhibitors or activators, which could lead to novel treatments for diseases associated with SUMOylation dysregulation. Overall, the investigation of SENP7 recombinant protein serves as a foundational step in unraveling the complexities of SUMO signaling and its implications in human health.
