Analytical Data
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基因名
YY1
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简介
The multifunctional transcription factor YY1 controls a variety of cellular and viral genes by binding to sites that overlap with the transcription start site. YY1 recognizes the consensus sequence 5'-CCGCCATNTT-3' and exhibits context-dependent transcriptional regulation, with methylation of the initial CG dinucleotide affecting binding affinity. YY1 Protein, Human (His) is the recombinant human-derived YY1 protein, expressed by E. coli , with C-6*His labeled tag.
- Application
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别名
Transcriptional repressor protein YY1; Delta transcription factor; INO80 complex subunit S; NF-E1; Yin and yang 1; INO80S
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种属
Human
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表达系统
E. coli
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标签
C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P25490
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表达区间
V221-G321
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蛋白长度
Partial
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分子量
17-20 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
YY1 (Yin Yang 1) is a transcription factor that plays a crucial role in various cellular processes, including gene regulation, cell differentiation, and development. Its unique ability to function as both a transcriptional activator and repressor makes it a key player in maintaining cellular homeostasis. Recent studies have highlighted the significance of YY1 in multiple biological contexts, such as cancer progression, stem cell biology, and immune responses, indicating its potential as a therapeutic target. The recombinant YY1 protein is essential for investigating its molecular mechanisms and interactions with other biomolecules. With advances in protein engineering and expression systems, researchers are increasingly able to produce large quantities of recombinant YY1 for use in functional assays, structural studies, and drug development. Understanding the structural and functional characteristics of YY1 could reveal novel insights into its role in health and disease, paving the way for innovative therapeutic strategies aimed at modulating its activity in pathological conditions. Thus, research on YY1 recombinant protein not only expands our knowledge of transcriptional regulation but also holds promise for developing targeted interventions in diseases linked to YY1 dysregulation.
