Cat: IPD-X31995

Recombinant Human Coagulation factor VII/F7 Protein (Yeast),His

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Analytical Data

  • 基因名

    Coagulation factor VII/F7

  • Application

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    Proconvertin Serum prothrombin conversion accelerator

  • 种属

    Human

  • 表达系统

    Yeast

  • 标签

    N- His

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    P08709

  • 表达区间

    61-212aa

  • 分子量

    19 kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

Coagulation factor VII (F7) is a crucial protein in the blood coagulation cascade, playing a key role in the initiation of clot formation. Deficiencies in F7 can lead to bleeding disorders, necessitating the development of therapeutic interventions. The advent of recombinant DNA technology has led to the production of recombinant coagulation factors, including F7, which can provide new treatment options for affected individuals. Research into recombinant factor VII products has gained momentum due to the limitations of traditional treatments, such as plasma-derived products, which may pose risks of viral transmission and allergic reactions. Clinical studies have demonstrated the effectiveness of recombinant F7 in managing bleeding episodes and preventing complications during surgical procedures in patients with hemophilia and F7 deficiency. Furthermore, the use of recombinant proteins allows for higher purity and more consistent dosing, addressing many challenges associated with existing therapies. As our understanding of the coagulation cascade and genetic factors influencing bleeding diatheses evolves, recombinant factor VII continues to be investigated for its potential applications, including in patients with other coagulopathies and trauma-induced coagulopathy. Overall, ongoing research into the safety, efficacy, and novel applications of recombinant F7 aims to enhance patient outcomes and expand therapeutic options in the field of hematology.

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IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
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