Analytical Data
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基因名
TALDO1
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简介
The TALDO1 protein plays a key role in cellular metabolism by catalyzing the rate-limiting step in the non-oxidative phase of the pentose phosphate pathway. Multiple studies have shown that it promotes the reversible conversion of sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate into erythrose 4-phosphate and β-D-fructose 6-phosphate. TALDO1 Protein, Human (HEK293, His) is the recombinant human-derived TALDO1 protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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别名
Transaldolase; TALDO1; TAL; TALDO; TALDOR
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种属
Human
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P37837
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表达区间
M1-K337
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氨基酸序列
MSSSPVKRQRMESALDQLKQFTTVVADTGDFHAIDEYKPQDATTNPSLILAAAQMPAYQELVEEAIAYGRKLGGSQEDQIKNAIDKLFVLFGAEILKKIPGRVSTEVDARLSFDKDAMVARARRLIELYKEAGISKDRILIKLSSTWEGIQAGKELEEQHGIHCNMTLLFSFAQAVACAEAGVTLISPFVGRILDWHVANTDKKSYEPLEDPGVKSVTKIYNYYKKFSYKTIVMGASFRNTGEIKALAGCDFLTISPKLLGELLQDNAKLVPVLSAKAAQASDLEKIHLDEKSFRWLHNEDQMAVEKLSDGIRKFAADAVKLERMLTERMFNAENGK
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蛋白长度
Full Length
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分子量
38.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TALDO1, or Transaldolase 1, is a crucial enzyme in the pentose phosphate pathway, which plays a significant role in cellular metabolism and redox balance. It facilitates the transfer of carbohydrates among sugars, contributing to the synthesis of nucleotides and nucleic acids, as well as to the generation of reducing equivalents in the form of NADPH. Dysregulation of TALDO1 is implicated in several metabolic disorders and diseases, including diabetes and cancer, highlighting the importance of understanding its biological function and regulation. Recent studies have shown that the enzyme's activity not only impacts metabolic flux but also influences cellular responses to stress and proliferation. Given its potential as a therapeutic target, researchers are increasingly interested in recombinant TALDO1 for biochemical studies, structural analysis, and drug development. The recombinant protein can be utilized to elucidate its catalytic mechanisms, explore its interactions with inhibitors and substrates, and assess its role in various metabolic pathways. By investigating TALDO1, scientists aim to deepen our understanding of metabolic pathways and their implications for health and disease, ultimately leading to novel treatment strategies for metabolic dysregulation.
