Analytical Data
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基因名
SOX17
- Application
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别名
Transcription factor SOX-17; SOX17; Homo sapiens; Human; Activator; DNA-binding
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种属
Human
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H6I2
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表达区间
S66-Q144
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蛋白长度
Partial
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SOX17 (SRY-related HMG-box gene 17) is a crucial transcription factor that plays a significant role in embryonic development, particularly in the differentiation of endodermal lineages and the regulation of stem cell pluripotency. Given its involvement in key developmental processes, SOX17 has gained considerable attention in cancer research, as its expression levels can be altered in various cancers, contributing to tumor progression and metastasis. Furthermore, SOX17 has been identified as a potential marker for identifying specific stem cell populations in both normal and pathological tissues. The production and study of recombinant SOX17 protein enable researchers to dissect its molecular mechanisms of action and understand its interactions with other proteins and DNA regulatory elements. These studies are essential for elucidating the functional pathways modulated by SOX17 and for exploring its therapeutic potential, especially in regenerative medicine and cancer therapy. By generating recombinant SOX17 proteins, scientists can conduct various assays, including binding affinity studies and functional assays in cellular models, to further investigate its role in cellular processes. Additionally, understanding the structural and functional properties of SOX17 at a molecular level may lead to the development of targeted therapies that can modulate its activity in diseases where it is dysregulated. Overall, the study of recombinant SOX17 proteins holds promise for advancing our understanding of developmental biology and for devising novel therapeutic strategies against diseases associated with SOX17 dysregulation.
