Analytical Data
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Gene name
ADAM8
- Application
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Alternative Names
CD156-A; MS2; CD156a; Disintegrin and metalloproteinase domain-containing protein 8
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
P78325
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Expression Region
Ser371~Glu587
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Molecular Weight
33kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Caspase-14 (CASP14) is a member of the cysteine protease family, playing a crucial role in the regulation of apoptosis, inflammation, and cellular differentiation. Unlike other caspases primarily involved in apoptotic pathways, CASP14 is uniquely associated with epidermal development and homeostasis. Its expression is predominantly found in the skin, where it is implicated in the formation of the epidermal water barrier and in the maturation of keratinocytes. Recent studies have suggested that aberrant CASP14 activity may contribute to various skin disorders and inflammatory conditions, highlighting its potential as a therapeutic target. The recombinant expression of CASP14 protein is essential for understanding its structural and functional properties, facilitating detailed investigations into its enzymatic mechanisms and interactions with substrates. By employing advanced recombinant DNA technologies, researchers aim to produce active CASP14 protein to elucidate its role in cell signaling pathways and skin physiology. Additionally, understanding how CASP14 may interact with other caspases and regulatory proteins could uncover new insights into its involvement in both normal and pathological states of skin health. Such knowledge could also lead to the development of novel strategies for the treatment of skin-related diseases, making CASP14 an important focus of current biomedical research.
