Analytical Data
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Gene name
NRBF2
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简介
NRBF2 protein may regulate transcriptional activation through target nuclear receptors and act as a transcriptional activator in vitro. It participates in starvation-induced autophagy, binding to PI3K complex I (PI3KC3-C1) and stabilizing its assembly. NRBF2 Protein, Human (sf9, His-GST) is the recombinant human-derived NRBF2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
- Application
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Alternative Names
Nuclear receptor-binding factor 2; Comodulator of PPAR and RXR; COPR
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Species
Human
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Source
Baculovirus
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Tag
N-His;N-GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96F24-1
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Expression Region
M1-N287
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Protein Length
Full Length of Isoform-1
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Molecular Weight
61 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NRBF2, or Nutrient-Regulated Gene Product 2, is a crucial protein implicated in various cellular processes, including nutrient sensing and metabolic regulation. Research into NRBF2 has gained significance due to its potential role in understanding metabolic disorders and diseases such as obesity and diabetes. This protein is known to interact with key signaling pathways that mediate nutrient availability and cellular response, making it a vital focal point for studying how cells adapt to fluctuating nutrient environments. Recent studies have indicated that NRBF2 may influence the activity of essential metabolic enzymes and transcription factors, thereby regulating gene expression related to energy homeostasis. Furthermore, its involvement in cellular stress responses and potential implications in cancer progression have sparked interest in exploring NRBF2 as a therapeutic target. As scientists continue to investigate NRBF2's structure, functions, and interactions, the hope is to elucidate its precise mechanisms and contributions to health and disease, paving the way for novel strategies in metabolic health management and cancer treatment. Understanding NRBF2's role offers a promising avenue for developing interventions that could modulate its activity, providing insights into how we can better manage conditions associated with metabolic dysregulation.
