Analytical Data
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基因名
TGF beta 3/TGFB3
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简介
Latent transforming growth factor beta-3 (TGF-beta-3) preprotein serves as a precursor to latency-associated peptide (LAP) and active TGF-beta-3 chains, which serve as regulatory and functional subunits. It plays a crucial role in maintaining the latent state of TGF-β-3 within the extracellular matrix. Latent TGF beta 3/Latent TGFB3 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived Latent TGF beta 3/Latent TGFB3 protein, expressed by HEK293 , with C-Avi, N-His labeled tag. The total length of Latent TGF beta 3/Latent TGFB3 Protein, Human (Biotinylated, HEK293, His-Avi) is 389 a.a., with molecular weight of 40-45 kDa.
- Application
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别名
TGFB3; ARVD; TGF-beta3
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种属
Human
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表达系统
HEK293
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标签
C-Avi;N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P10600
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表达区间
L24-S412
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蛋白长度
Partial
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分子量
15 kDa & 40-45 kDa & 60 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TGF-beta 3 (TGFB3) is a member of the transforming growth factor-beta superfamily, which plays a crucial role in various biological processes, including cell growth, differentiation, and immune regulation. In recent years, TGFB3 has garnered significant attention for its potential therapeutic applications, particularly in tissue regeneration and fibrosis. Studies have demonstrated that TGFB3 enhances extracellular matrix production and promotes wound healing by facilitating the migration and proliferation of cells involved in tissue repair. Dysregulation of TGFB3 signaling is associated with several pathological conditions, including cancer and chronic inflammatory diseases, making it a target for intervention. Recombinant TGFB3 proteins are being developed and explored in clinical settings to harness their therapeutic benefits, particularly in regenerative medicine, where they could aid in strategies for tissue engineering and repair. Researchers are investigating the molecular mechanisms underlying TGFB3 function, as well as its interactions with other growth factors and extracellular matrix components. By understanding these dynamics, the advancement of TGFB3-based therapies holds promise for improving clinical outcomes in a variety of applications, including wound healing, bone regeneration, and treatment of fibrotic diseases.
