Analytical Data
-
Gene name
TGF beta 3/TGFB3
-
简介
TGF-β3 (transforming growth factor-β3) is a member of a TGF-beta superfamily subgroup that performs many cellular functions. TGF-β3 has a role in embryogenesis and cell differentiation. TGF-β3 also plays a critical role in palatogenesis, the wound healing process. TGF-β3 is capable of binding directly to the type II receptor (TβRII)[1][2]. TGF beta 3/TGFB3 Protein, Human (HEK293) is produced in HEK293 cells, and consists of 112 amino acids (A301-S412).
- Application
-
Alternative Names
rHuTGF-β3; TGFB3; LAP
-
Species
Human
-
Source
HEK293
-
Tag
Tag Free
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P10600
-
Expression Region
A301-S412
-
Protein Length
Partial
-
Molecular Weight
12-14 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TGF-beta 3 (TGFB3) is a member of the transforming growth factor-beta superfamily, which plays a crucial role in various biological processes, including cell growth, differentiation, and immune regulation. In recent years, TGFB3 has garnered significant attention for its potential therapeutic applications, particularly in tissue regeneration and fibrosis. Studies have demonstrated that TGFB3 enhances extracellular matrix production and promotes wound healing by facilitating the migration and proliferation of cells involved in tissue repair. Dysregulation of TGFB3 signaling is associated with several pathological conditions, including cancer and chronic inflammatory diseases, making it a target for intervention. Recombinant TGFB3 proteins are being developed and explored in clinical settings to harness their therapeutic benefits, particularly in regenerative medicine, where they could aid in strategies for tissue engineering and repair. Researchers are investigating the molecular mechanisms underlying TGFB3 function, as well as its interactions with other growth factors and extracellular matrix components. By understanding these dynamics, the advancement of TGFB3-based therapies holds promise for improving clinical outcomes in a variety of applications, including wound healing, bone regeneration, and treatment of fibrotic diseases.
