Analytical Data
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基因名
IL-2Rb
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简介
IL-2R beta (CD122), a type Ⅰ cytokine receptor expressed on T lymphocytes, is a receptor for IL-2 (Kd: 1 nM approximately)[1]. IL-2R beta mediates T cell immune responses, such as stimulating T cell proliferation and activating lymphokine-activated killer cells[2]. IL-2R beta/CD122 Protein, Human (HEK293, Fc) is a recombinant human extracellular region of IL-2R beta (A27-D239) with a C-Terminal Fc tag, which is produced in HEK298 cells.
- Application
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别名
IL-2 R beta & IL-2 R gamma; IL-2RB & IL-2RG
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种属
Mouse
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表达系统
HEK293
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标签
C-Twin-Strep;C-His
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纯度
> 90% as determined by SDS-PAGE.
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蛋白编号
P16297 (A27-E240)&P34902
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表达区间
P16297-1 (A27-E240)&P34902-1 (W23-A263)
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蛋白长度
Extracellular Domain
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分子量
50-55 kDa and 55-65 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Interleukin-2 receptor beta (IL-2Rb) is a critical component of the interleukin-2 (IL-2) signaling pathway, which plays a vital role in the regulation of immune responses, particularly T cell proliferation and differentiation. The IL-2Rb subunit forms part of the high-affinity IL-2 receptor complex, alongside the alpha (IL-2Ra) and gamma (IL-2Rg) chains. Impairments or mutations in IL-2Rb can lead to severe immunological disorders, such as Combined Immunodeficiency syndrome (SCID), highlighting its importance in maintaining immune system functionality. The recombinant production of IL-2Rb protein is essential for understanding its structure, function, and interactions within the receptor complex. With advancements in recombinant DNA technology, researchers have been able to express and purify IL-2Rb, facilitating studies into its molecular mechanisms. Additionally, understanding IL-2Rb interactions aids in the development of therapeutic strategies targeting autoimmune diseases and enhancing cancer immunotherapy. Thus, the study of IL-2Rb recombinant protein is crucial for elucidating its role in immune regulation and developing novel clinical applications.
