Analytical Data
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基因名
IL-24R beta
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简介
IL-20R beta Protein (IL20RB) is the beta subunit of IL-20 receptor, forms functional heterodimers with different subunit protein and involves in STAT3 activation pathway[1]. The IL-20RA/IL-20RB dimer is a receptor for IL-19, IL-20 and IL-24. The IL-22RA1/IL-20RB dimer is a receptor for IL-20 and IL-24[2]. IL-20R beta Protein is consists of 311 amino acids (M1-S311) with a transmembrane domain (234-254 a.a.). IL-20R beta Protein, Human (sf9, His) is produced in Sf9 insect cells with a C-Terminal His-tag.
- Application
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别名
Interleukin-20 receptor subunit beta; IL-20R-beta; IL-20RB; FNDC6; IL-20R2; DIRS1
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种属
Human
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表达系统
Baculovirus
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标签
C-His
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纯度
> 90% as determined by SDS-PAGE.
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蛋白编号
Q6UXL0
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表达区间
D30-A230
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蛋白长度
Extracellular Domain
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分子量
23.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IL-24R beta, a critical component of the interleukin-24 receptor complex, plays a significant role in mediating the functions of IL-24, a cytokine known for its pro-apoptotic and anti-tumor effects. Understanding the structure and function of IL-24R beta is essential for elucidating the mechanisms by which IL-24 exerts its biological activities, particularly in cancer therapy. Research has shown that IL-24 can induce apoptosis in various cancer cell types while sparing normal cells, positioning it as a promising agent in targeted cancer treatments. However, the specific signaling pathways and interactions involving IL-24R beta remain poorly characterized. Recent studies involving the recombinant expression of IL-24R beta have aimed to provide insights into its role in receptor signaling and the therapeutic potential of IL-24-based interventions. By generating and assessing IL-24R beta recombinant proteins, researchers aim to facilitate the development of novel therapeutic strategies that leverage the unique properties of this cytokine and its receptor, potentially leading to more effective treatments for cancer and other diseases associated with dysregulated IL-24 signaling. This ongoing research not only enhances our understanding of cytokine receptor interactions but also opens avenues for innovative therapeutic applications in oncology.
