Analytical Data
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基因名
SENP2
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简介
The SENP2 protein is crucial in the SUMO pathway and has the dual function of maturing and uncoupling SUMO. It hydrolyzes the α-linked peptide bond in the SUMO propeptide, converting it to the mature form. SENP2 Protein, Human is the recombinant human-derived SENP2 protein, expressed by E. coli , with tag free.
- Application
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别名
Sentrin-specific protease 2; Axam2; SMT3-specific isopeptidase 2; Sentrin/SUMO-specific protease SENP2; KIAA1331; SENP2.
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种属
Human
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9HC62-1
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表达区间
D363-L589
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氨基酸序列
DDLLELTEDMEKEISNALGHGPQDEILSSAFKLRITRGDIQTLKNYHWLNDEVINFYMNLLVERNKKQGYPALHVFSTFFYPKLKSGGYQAVKRWTKGVNLFEQEIILVPIHRKVHWSLVVIDLRKKCLKYLDSMGQKGHRICEILLQYLQDESKTKRNSDLNLLEWTHHSMKPHEIPQQLNGSDCGMFTCKYADYISRDKPITFTQHQMPLFRKKMVWEILHQQLL
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蛋白长度
Partial
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分子量
29.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SENP2, or Sentrin Specific Protease 2, is a key member of the Sentrin/SUMO-specific protease family, which plays a crucial role in the post-translational modification of proteins through the removal of SUMO (Small Ubiquitin-like Modifier) tags. The regulation of protein functions via SUMOylation is vital for various cellular processes, including signal transduction, gene expression, DNA repair, and cellular stress responses. Aberrant SENP2 activity has been implicated in several pathological conditions, including cancer and neurodegenerative diseases, making it an important target for therapeutic interventions. Recent research has focused on the structural and functional characterization of SENP2, highlighting its enzymatic mechanisms and substrate interactions. The development of recombinant SENP2 proteins has facilitated detailed studies into its activity and regulation, providing insights into the biological significance of SUMOylation pathways. Furthermore, the potential of SENP2 as a biomarker for diseases and a target for drug development underscores the importance of ongoing research in understanding its role in cellular physiology and pathology. The significant implications for therapeutic advancements make SENP2 a focal point of interest in the fields of molecular biology and biomedicine.
