Analytical Data
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Gene name
RNASE6
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简介
RNASE6 Protein, a pyrimidine-preferring ribonuclease, exhibits potent antibacterial activity against diverse bacteria, including P. aeruginosa, A. baumanii, and E. coli. Its effect is independent of ribonuclease activity, inducing bacterial membrane disruption and Gram-negative bacteria agglutination, emphasizing its bactericidal properties. RNASE6's robust antibacterial activity suggests a potential role in preserving urinary tract sterility. RNASE6 Protein, Human (HEK293, His) is the recombinant human-derived RNASE6 protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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Alternative Names
Ribonuclease K6; RNase K6; RNASE6; RNS6
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Species
Human
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q93091
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Expression Region
W24-L150
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Protein Length
Full Length of Mature Protein
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Molecular Weight
18-25 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RNASE6, a member of the ribonuclease A superfamily, plays a crucial role in various physiological processes, particularly in innate immunity and host defense against viral infections. Its involvement in RNA degradation and modulation of inflammatory responses makes it a significant focus of study. Recent research highlights its potential therapeutic applications, as its enzymatic activity can influence the stability and function of RNA molecules, thereby affecting gene expression and immune responses. Studies have also shown that RNASE6 is expressed in multiple tissues, particularly in the respiratory and gastrointestinal tracts, implicating it in the pathology of various diseases. For example, aberrant RNASE6 expression has been linked to conditions such as asthma, chronic obstructive pulmonary disease, and certain cancers. Given its multifaceted roles, there is increasing interest in developing RNASE6 recombinant proteins for experimental and potential therapeutic use. Investigating the structure-function relationship of RNASE6 through recombinant protein studies can provide insights into its enzymatic mechanisms and interactions with RNA substrates. Moreover, understanding how post-translational modifications and protein dynamics influence RNASE6 activity will be critical for leveraging its potential in therapeutic applications. This research not only aims to delineate the biological roles of RNASE6 but also to explore its applicability in the development of novel strategies for treatment of infectious diseases and inflammatory conditions.
