Analytical Data
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基因名
CD206/MMR
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简介
The MRC2 protein may function as an endocytic lectin receptor with calcium-dependent lectin activity. It internalizes glycosylated ligands via clathrin-mediated endocytosis and releases them in endosomes. MRC2 Protein, Human (HEK293, His) is the recombinant human-derived MRC2 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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别名
C-type lectin domain family 13 member E, Endocytic receptor 180, Macrophage mannose receptor 2, Urokinase-type plasminogen activator receptor-associated protein (UPAR-associated protein; Urokinase receptor-associated protein)
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种属
Human
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表达系统
HEK293
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标签
C-8*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UBG0
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表达区间
G31-P530
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蛋白长度
Partial
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分子量
65-75 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD206, also known as the macrophage mannose receptor (MMR), is a type I transmembrane protein primarily expressed on the surface of macrophages and dendritic cells. It plays a critical role in the recognition and uptake of glycoproteins and glycolipids through specific binding to mannose, fucose, and N-acetylglucosamine residues, thus facilitating important immunological processes such as antigen presentation and phagocytosis. Given its pivotal role in immune response and homeostasis, CD206/MMR has garnered significant interest in various fields of biomedical research, including cancer therapy, infectious diseases, and autoimmune disorders. Recent studies have explored its potential as a therapeutic target, considering its differential expression in tumor-associated macrophages compared to normal tissues, making it a promising candidate for targeted drug delivery systems. Additionally, recombinant CD206/MMR protein has been utilized in vaccine development and as a tool for studying macrophage function and polarization. The characterization and manipulation of this receptor could lead to innovative approaches in modulating immune responses and improving therapeutic outcomes in diseases where macrophage function is compromised or dysregulated. Overall, research on CD206/MMR continues to illuminate its crucial role in immunity and offers opportunities for therapeutic advancements.
