Analytical Data
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Gene name
CD206/MMR
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简介
The CD206/MMR protein acts as a multifunctional mediator in macrophages, promoting glycoprotein internalization. It has a broad binding capacity, interacting with both sulfated and non-sulfated polysaccharide chains. CD206/MMR Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD206/MMR protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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Biological Activity
Measured by its binding ability in a functional ELISA. When Mannan is coated at 0.2 μg/mL (100 μL/well) can bind Recombinan Mouse CD206. The ED50 for this effect is 0.485μg/mL. Measured by its binding ability in a functional ELISA. When Mannan is coated at 0.2 μg/mL (100 μL/well) can bind Recombinan Mouse CD206. The ED50 for this effect is 0.485 μg/mL.
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Alternative Names
CD206; CLEC13D; CLEC13Dmacrophage mannose receptor 1; C-type lectin domain family 13 member D; mannose receptor, C type 1; MMR; MMRCD206 antigen; MRC1
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Species
Mouse
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q2HZ94
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Expression Region
L19-A1388
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AA Sequence
LLDARQFLIYNEDHKRCVDALSAISVQTATCNPEAESQKFRWVSDSQIMSVAFKLCLGVPSKTDWASVTLYACDSKSEYQKWECKNDTLFGIKGTELYFNYGNRQEKNIKLYKGSGLWSRWKVYGTTDDLCSRGYEAMYSLLGNANGAVCAFPFKFENKWYADCTSAGRSDGWLWCGTTTDYDKDKLFGFCPLHFEGSERLWNKDPLTGILYQINSKSALTWHQARASCKQQNADLLSVTEIHEQMYLTGLTSSLSSGLWIGLNSLSVRSGWQWAGGSPFRYLNWLPGSPSSEPGKSCVSLNPGKNAKWENLECVQKLGYICKKGNNTLNPFIIPSASDVPTGCPNQWWPYAGHCYRIHREEKKIQKYALQACRKEGGDLASIHSIEEFDFIFSQLGYEPNDELWIGLNDIKIQMYFEWSDGTPVTFTKWLPGEPSHENNRQEDCVVMKGKDGYWADRACEQPLGYICKMVSQSHAVVPEGADKGCRKGWKRHGFYCYLIGSTLSTFTDANHTCTNEKAYLTTVEDRYEQAFLTSLVGLRPEKYFWTGLSDVQNKGTFRWTVDEQVQFTHWNADMPGRKAGCVAMKTGVAGGLWDVLSCEEKAKFVCKHWAEGVTRPPEPTTTPEPKCPENWGTTSKTSMCFKLYAKGKHEKKTWFESRDFCKAIGGELASIKSKDEQQVIWRLITSSGSYHELFWLGLTYGSPSEGFTWSDGSPVSYENWAYGEPNNYQNVEYCGELKGDPGMSWNDINCEHLNNWICQIQKGKTLLPEPTPAPQDNPPVTADGWVIYKDYQYYFSKEKETMDNARAFCKKNFGDLATIKSESEKKFLWKYINKNGGQSPYFIGMLISMDKKFIWMDGSKVDFVAWATGEPNFANDDENCVTMYTNSGFWNDINCGYPNNFICQRHNSSINATAMPTTPTTPGGCKEGWHLYKNKCFKIFGFANEEKKSWQDARQACKGLKGNLVSIENAQEQAFVTYHMRDSTFNAWTGLNDINAEHMFLWTAGQGVHYTNWGKGYPGGRRSSLSYEDADCVVVIGGNSREAGTWMDDTCDSKQGYICQTQTDPSLPVSPTTTPKDGFVTYGKSSYSLMKLKLPWHEAETYCKDHTSLLASILDPYSNAFAWMKMHPFNVPIWIALNSNLTNNEYTWTDRWRVRYTNWGADEPKLKSACVYMDVDGYWRTSYCNESFYFLCKKSDEIPATEPPQLPGKCPESEQTAWIPFYGHCYYFESSFTRSWGQASLECLRMGASLVSIETAAESSFLSYRVEPLKSKTNFWIGMFRNVEGKWLWLNDNPVSFVNWKTGDPSGERNDCVVLASSSGLWNNIHCSSYKGFICKMPKIIDPVTTHSSITTKADQRKMDPQPKGSSKA
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Protein Length
Partial
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Molecular Weight
158 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD206, also known as the macrophage mannose receptor (MMR), is a type I transmembrane protein primarily expressed on the surface of macrophages and dendritic cells. It plays a critical role in the recognition and uptake of glycoproteins and glycolipids through specific binding to mannose, fucose, and N-acetylglucosamine residues, thus facilitating important immunological processes such as antigen presentation and phagocytosis. Given its pivotal role in immune response and homeostasis, CD206/MMR has garnered significant interest in various fields of biomedical research, including cancer therapy, infectious diseases, and autoimmune disorders. Recent studies have explored its potential as a therapeutic target, considering its differential expression in tumor-associated macrophages compared to normal tissues, making it a promising candidate for targeted drug delivery systems. Additionally, recombinant CD206/MMR protein has been utilized in vaccine development and as a tool for studying macrophage function and polarization. The characterization and manipulation of this receptor could lead to innovative approaches in modulating immune responses and improving therapeutic outcomes in diseases where macrophage function is compromised or dysregulated. Overall, research on CD206/MMR continues to illuminate its crucial role in immunity and offers opportunities for therapeutic advancements.
