Analytical Data
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Gene name
NRN1L
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简介
NRN1L Protein is encoded by nrn1l gene in extracellular and enhances both neurite growth and neuronal survival. NRN1L protein is found both as a GPI anchored membrane-bound form and as a secreted form. This activity-related ligand functions as a homodimer or heterodimer. NRN1L Protein belongs to the neuritin (Nrn1) family. NRN1 is involved in neural development, synaptic plasticity, and synapse maturation[1][2]. NRN1L Protein, Human (HEK293, His) is the recombinant human-derived NRN1L protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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Alternative Names
Neuritin-like protein; NRN1L; UNQ2446/PRO5725
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Species
Human
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q496H8
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Expression Region
A36-A139
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Protein Length
Full Length of Mature Protein
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Molecular Weight
14 kDa & 16 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NRN1L, or Neuritin-1-like protein, has garnered significant attention in recent years due to its critical role in neuronal development and synaptic plasticity. This protein, a member of the neuritin family, is primarily involved in promoting neuronal survival and differentiation, thereby influencing cognitive functions and potentially impacting neurodegenerative diseases. Research indicates that NRN1L exhibits neuroprotective properties, particularly in conditions of oxidative stress and excitotoxicity, which are hallmarks of various neurological disorders. Furthermore, NRN1L has been linked to the modulation of synaptic transmission and plasticity, processes essential for learning and memory. Given its potential therapeutic implications, researchers are exploring the recombinant expression of NRN1L for further functional studies, aiming to elucidate its mechanisms and identify targets for drug development. The production of NRN1L as a recombinant protein can facilitate detailed investigations into its structure-function relationships, ligand interactions, and downstream signaling pathways that contribute to its neuroprotective effects. Overall, the study of NRN1L as a recombinant protein holds promise for advancing our understanding of its biological significance in the nervous system and for developing novel therapeutic strategies to combat neurodegenerative diseases and enhance cognitive function.
