Analytical Data
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Gene name
DPEP1
- Application
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Alternative Names
(Beta-lactamase)(Dehydropeptidase-I)(Microsomal dipeptidase)(Renal dipeptidase)(hRDP)
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Species
Human
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Source
Yeast
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Tag
C- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P16444
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Expression Region
17-385aa
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Molecular Weight
42.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
DPEP1 (Dipeptidase 1), also known as renal dipeptidase or solute carrier family 15 member 1 (SLC15A1), is a membrane-bound enzyme that predominantly expresses in the kidneys and plays a crucial role in the hydrolysis of dipeptides, facilitating amino acid absorption. Research into DPEP1 has gained momentum due to its implications in renal physiology, peptide metabolism, and various pathological conditions, including hypertension, diabetes, and kidney diseases. The enzyme's activity in the proximal tubules of the kidneys contributes to the reclamation of amino acids and the overall maintenance of nitrogen balance in the body. Furthermore, disruptions in DPEP1 function can lead to impaired peptide transport and altered amino acid profiles, potentially exacerbating metabolic disorders. Scientists are particularly interested in DPEP1 as a therapeutic target, exploring its modulation for enhancing amino acid reabsorption and improving nutritional outcomes in patients with renal impairment. Additionally, recombinant DPEP1 protein has become a valuable tool in structural biology and enzymology studies, allowing researchers to investigate its catalytic mechanisms and interactions at a molecular level. Understanding the biochemical and regulatory pathways involving DPEP1 can thus provide insights into its broader physiological roles and therapeutic potential, paving the way for innovative approaches in the management of related diseases.
