Analytical Data
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Gene name
NHP2L1
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简介
NHP2L1 is integral to ribosome biogenesis and is a key member of the small subunit (SSU) processing group, the precursor of the eukaryotic ribosomal small subunit. The SSU processing group assembles in the nucleolus and cooperates with the folding, modification, rearrangement, cleavage and targeted degradation of nascent pre-rRNA promoted by RNA exosomes. NHP2L1 Protein, Human (His) is the recombinant human-derived NHP2L1 protein, expressed by E. coli , with N-6*His labeled tag.
- Application
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Alternative Names
NHP2-Like Protein 1; High Mobility Group-Like Nuclear Protein 2 Homolog 1; OTK27; SNU13 Homolog; hSNU13; U4/U6.U5 tri-snRNP 15.5 kDa Protein; NHP2L1
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Species
Human
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Source
E. coli
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Tag
N-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P55769
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Expression Region
M1-V128
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Protein Length
Full Length
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Molecular Weight
16 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NHP2L1, a member of the DExH-box helicase family, has garnered attention for its potential role in various cellular processes, including RNA metabolism and ribosome biogenesis. Its involvement in critical biological functions makes it a subject of interest for researchers studying gene expression regulation and cellular stress response. Recent studies have suggested that NHP2L1 may play a significant role in disease mechanisms, particularly in cancer progression and viral infections. The expression and functional analysis of recombinant NHP2L1 protein provide insights into its biochemical properties and interactions with other cellular components. This research aims to elucidate the mechanistic underpinnings of NHP2L1 and its contributions to disease, as well as to develop potential therapeutic strategies targeting this protein. Understanding NHP2L1's role at a molecular level could pave the way for advancements in biomedical research, particularly in the fields of cancer biology and virology, where modulation of its function may offer novel avenues for treatment and intervention.
