Cat: IPD-X35608

Recombinant Human CLEC2B Protein (HEK293),hFc

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Analytical Data

  • Gene name

    CLEC2B

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Biological Activity

    Measured by its binding ability in a functional ELISA. When Recombinant Human AICL/CLEC-2B is coated at 2 µg/mL can bind Biotinylated Human Galectin-1 (HY-P70273). The ED50 for this effect is 3.87 µg/mL. Measured by its binding ability in a functional ELISA. When Recombinant Human AICL/CLEC-2B is coated at 2 µg/mL can bind Biotinylated Human Galectin-1 (HY-P70273). The ED50 for this effect is 3.87 µg/mL.

  • Alternative Names

    C-type lectin domain family 2 member B; AICL; CLECSF2; IFNRG1

  • Species

    Human

  • Source

    HEK293

  • Tag

    N-hFc

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    Q92478

  • Expression Region

    K26-H149

  • Protein Length

    Extracellular Domain

  • Molecular Weight

    50-65 kDa.

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

CLEC2B is a C-type lectin-like receptor that plays a crucial role in the immune system by mediating various cellular responses. Understanding its structure and function is pivotal for elucidating its involvement in immune responses, particularly in the context of viral infections and inflammation. The study of CLEC2B is significant due to its potential therapeutic applications, as targeting this receptor can enhance immune responses or modulate inflammatory pathways. Recent research has focused on characterizing the recombinant forms of CLEC2B, which could provide insights into its ligand interactions and downstream signaling mechanisms. By utilizing advanced techniques in molecular biology and structural biology, scientists aim to elucidate the precise role of CLEC2B in immune regulation and its potential as a target for drug development. This research not only enhances our understanding of the innate immune system but also opens new avenues for therapeutic interventions in immune-related diseases.

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