Analytical Data
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Gene name
EPDR1
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简介
In the rat model, the EPDR1 protein plays a key regulator role by binding to and activating the TIE2 receptor, initiating its tyrosine phosphorylation. This interaction affects processes of endothelial development that are distinct from the effects of VEGF, which mediates interactions between the endothelium and the surrounding matrix and interstitium. EPDR1 Protein, Human (HEK293, His) is the recombinant human-derived EPDR1 protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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Alternative Names
Mammalian ependymin-related protein 1; EPDR1; Upregulated in colorectal cancer gene 1 protein; MERP1
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Species
Human
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UM22-1
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Expression Region
A38-S223
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AA Sequence
APRPCQAPQQWEGRQVMYQQSSGRNSRALLSYDGLNQRVRVLDERKALIPCKRLFEYILLYKDGVMFQIDQATKQCSKMTLTQPWDPLDIPQNSTFEDQYSIGGPQEQITVQEWSDRKSARSYETWIGIYTVKDCYPVQETFTINYSVILSTRFFDIQLGIKDPSVFTPPSTCQMAQLEKMSEDCS
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Protein Length
Full Length of Isoform-1 Mature Protein
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Molecular Weight
28 kDa & 33 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EPDR1, or epithelial-derived protein 1, is a protein of significant interest in the field of molecular biology due to its involvement in various cellular processes, including cell proliferation, adhesion, and differentiation. Research indicates that EPDR1 is expressed in epithelial tissues and may play a crucial role in maintaining epithelial integrity and function. Abnormal expression of EPDR1 has been linked to several pathological conditions, including cancer, where it might contribute to tumorigenesis and metastasis. Understanding the molecular mechanisms underlying EPDR1 function could provide valuable insights into the development of therapeutic strategies for diseases characterized by epithelial dysfunction. The recombinant expression of EPDR1 in various host systems allows for in-depth functional studies and the exploration of its potential as a biomarker or therapeutic target. By producing EPDR1 as a recombinant protein, researchers can investigate its structural properties, interactions with other proteins, and its role in signaling pathways relevant to cancer and other diseases. As such, the study of EPDR1 is not only pivotal for elucidating fundamental biological processes but also holds promise for advancing clinical applications in oncology and regenerative medicine.
