Analytical Data
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Gene name
KIR2DL1
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简介
KIR2DL1, found on NK cells, serves as a receptor for specific HLA-C alleles, inhibiting NK cell activity to prevent cell lysis. This regulatory function involves interactions with ARRB2 and, additionally, engages PTPN6 and PTPN11. The interaction's enhancement by ARRB2 underscores KIR2DL1's role in complex signaling networks that modulate NK cell function. KIR2DL1 Protein, Human (HEK293, Fc) is the recombinant human-derived KIR2DL1 protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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Alternative Names
Killer cell immunoglobulin-like receptor 2DL1; NKAT-1; CD158a; KIR2DL1
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Species
Human
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P43626-1
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Expression Region
H22-H245
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Protein Length
Extracellular Domain
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Molecular Weight
70 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KIR2DL1, a member of the killer immunoglobulin-like receptor (KIR) family, plays a crucial role in the regulation of natural killer (NK) cell activity and contributes significantly to the immune response against viral infections and tumor cells. Its specific interaction with HLA-C molecules, particularly those encoding the C1 and C2 epitopes, mediates inhibitory signals that prevent the inappropriate activation of NK cells, thereby maintaining immune tolerance and self-recognition. The study of KIR2DL1 recombinant proteins is critical for understanding the mechanisms of NK cell regulation and how variations in KIR genes can influence susceptibility to diseases, including cancer and autoimmune disorders. By generating and characterizing KIR2DL1 recombinant proteins, researchers aim to elucidate the receptor's structural properties, ligand interactions, and signaling pathways. This knowledge not only sheds light on basic immunological processes but also has potential therapeutic implications, such as enhancing NK cell responses in cancer immunotherapy or designing novel immunomodulatory strategies. Moreover, the investigation of KIR2DL1 polymorphisms in different populations can provide insights into the evolutionary pressures shaping the immune system and inform personalized medicine approaches. Overall, the research surrounding KIR2DL1 recombinant proteins is pivotal in advancing our understanding of innate immunity and its clinical applications.
