Analytical Data
-
Gene name
CCR2
-
简介
CCR2 protein is an important chemokine receptor that coordinates chemotaxis and migration by binding to CCL2, CCL7, and CCL12 and activating the PI3K cascade. In addition to chemokine signaling, CCR2 regulates T cell inflammatory cytokines, promotes Th17 cell generation, and promotes mature thymocyte output. CCR2 Protein, Mouse (N-His, C-Myc) is the recombinant mouse-derived CCR2 protein, expressed by E. coli , with C-Myc, N-10*His labeled tag.
- Application
-
Alternative Names
CCR2; chemokine (C-C motif) receptor 2; CMKBR2; CC CKR 2; CD192; CKR2; FLJ78302; MCP 1 R; CCR2A; CCR2B; CKR2A; CKR2B; MCP-1-R; CC-CKR-2
-
Species
Mouse
-
Source
E. coli
-
Tag
C-Myc;N-10*His
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P51683
-
Expression Region
M1-A55
-
Protein Length
Extracellular Domain
-
Molecular Weight
16 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CCR2 (C-C chemokine receptor type 2) is a vital chemokine receptor involved in the immune response, specifically in the migration of monocytes and other immune cells to sites of inflammation. Its role is critical in various pathological conditions, including atherosclerosis, autoimmune diseases, and cancer. Research targeting CCR2 has gained prominence due to its potential as a therapeutic target, particularly in modulating immune responses and alleviating chronic inflammatory disorders. The study of CCR2 recombinant proteins is crucial in understanding its structure-function relationships, signaling mechanisms, and interactions with ligands. These recombinant proteins can be utilized in various applications, including vaccine development, receptor binding studies, and drug screening assays. Scientists have been focused on producing and characterizing CCR2 recombinant proteins to further investigate their biological functions and therapeutic implications. Understanding CCR2 dynamics through its recombinant forms has the potential to unveil novel strategies for the treatment of diseases associated with immune dysregulation. Additionally, exploring CCR2's role could lead to breakthroughs in precision medicine, offering possibilities for targeted therapies that minimize side effects while enhancing treatment efficacy. The ongoing research into CCR2 and its recombinant proteins represents a promising avenue for advancing our knowledge of immune regulation and developing innovative therapeutic approaches.
