Analytical Data
-
Gene name
OX40/TNFRSF4
-
简介
OX40 (TNFRSF4), is a receptor for OX40 Ligand. OX40 is preferentially expressed by T cells. OX40 can be activated by OX40 Ligand, thereby functioning as a T cell co-stimulatory molecule. The OX40-OX40 Ligand interaction promotes effector T-cell survival and effectively induces memory T-cell generation, as well as enhances the helper function of Tfh for B cells, and also promotes the differentiation and maturation of DCs[1][2]. OX40/TNFRSF4 Protein, Mouse (Biotinylated, HEK293, His-Avi) is a recombinant biotinylated mouse OX40 (V20-P211) with C-terminal Avi and His tag, which is produced in HEK293.
- Application
-
Species
Mouse
-
Source
HEK293
-
Tag
C-Avi;C-8*His
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P47741
-
Expression Region
V20-P211
-
Protein Length
Extracellular Domain
-
Molecular Weight
48-55 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
OX40, also known as TNFRSF4, is a member of the tumor necrosis factor receptor (TNFR) superfamily that plays a vital role in regulating immune responses, particularly in the activation and survival of T cells. Its interaction with the ligand OX40L enhances T cell proliferation, survival, and cytokine production, making it a critical co-stimulatory molecule in the immune system. Research has shown that OX40 signaling can improve anti-tumor immunity and has been implicated in various diseases, including autoimmune disorders and cancer. The development of OX40/TNFRSF4 recombinant proteins has become a focus of investigation, as these proteins can serve as therapeutic agents or tools for studying OX40 biology in detail. By understanding the mechanisms of OX40 engagement and its downstream signaling pathways, researchers aim to harness this knowledge for therapeutic interventions, including immunotherapies that could potentiate or restore T cell function in cancer and chronic infections. Exploring the structural and functional aspects of OX40/TNFRSF4 recombinant proteins will enhance our comprehension of their roles in immune regulation and could lead to novel strategies for enhancing anti-tumor immunity or modulating immune responses in autoimmune diseases.
