Analytical Data
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基因名
IL-5
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简介
IL-5 Protein, produced by T-lymphocytes and NK cells, is crucial for eosinophil survival, differentiation, and chemotaxis. It stimulates immunoglobulin production and growth in B-cells. IL-5 Protein activates kinases (LYN, SYK, and JAK2) through a receptor (IL5RA and CSF2RB subunits), propagating signals via RAS-MAPK and JAK-STAT5 pathways. It exists as a disulfide-linked homodimer. IL-5 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IL-5 protein, expressed by HEK293, with N-His labeled tag.
- Application
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别名
Interleukin-5; IL-5; EDF; Eo-CSF; TRF
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种属
Cynomolgus
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表达系统
HEK293
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标签
N-His
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纯度
> 90% as determined by SDS-PAGE.
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蛋白编号
A0A2K5U1E7
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表达区间
I20-S134
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分子量
19-23 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Interleukin-5 (IL-5) is a critical cytokine primarily produced by activated T-helper type 2 (Th2) cells and plays a significant role in regulating eosinophil production, differentiation, and activation in the immune response. Elevated levels of IL-5 are associated with various allergic conditions, including asthma, allergic rhinitis, and eosinophilic esophagitis, making it a pivotal target for therapeutic intervention. The study of recombinant IL-5 proteins has gained traction as researchers aim to understand its biological functions and signaling pathways more comprehensively. By producing IL-5 in recombinant systems, scientists can explore its interactions with specific receptors, elucidate its role in eosinophil biology, and investigate its implications in allergic diseases. Furthermore, recombinant IL-5 is also being explored for its potential use in vaccine development and as a biomarker for diagnosing and monitoring allergic conditions. The advancement of biotechnology and protein engineering techniques has paved the way for producing highly purified and biologically active IL-5, fostering research into novel therapeutic approaches aimed at modulating eosinophilic inflammation and improving patient outcomes in allergic diseases. As the understanding of IL-5 and its role in immune regulation deepens, ongoing research into its recombinant forms also aims to inform the development of more targeted therapies that may provide better efficacy and reduced side effects compared to conventional treatments.
