Analytical Data
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基因名
IL-17RA
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简介
IL-17RA (Interleukin 17 receptor A), a receptor for IL-17A and IL-17F, is a type I membrane glycoprotein. It is expressed ubiquitously and exhibits a broad tissue distribution, and plays a role in many inflammatory and autoimmune diseases. IL-17RA is a common co-receptor subunit for other members of the IL-17 family. IL-17RA associates with IL-17RC to form a signaling receptor complex for IL-17A and IL-17F[1][2]. IL-17RA Protein, Human (Biotinylated, HEK293, His-Avi), a Biotinylated IL-17RA protein, is produced in HEK293 cells with a C-Terminal His-tag and a C-Terminal Avi-tag.
- Application
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别名
CD217; CDw217; IL-17RA; IL17R; CANDF5; IL-7R; IL-7R-alpha; ILRA
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种属
Human
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表达系统
HEK293
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标签
C-Avi;C-8*His
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纯度
> 90% as determined by SDS-PAGE.
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蛋白编号
Q96F46
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表达区间
L33-W320
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氨基酸序列
LRLLDHRALVCSQPGLNCTVKNSTCLDDSWIHPRNLTPSSPKDLQIQLHFAHTQQGDLFPVAHIEWTLQTDASILYLEGAELSVLQLNTNERLCVRFEFLSKLRHHHRRWRFTFSHFVVDPDQEYEVTVHHLPKPIPDGDPNHQSKNFLVPDCEHARMKVTTPCMSSGSLWDPNITVETLEAHQLRVSFTLWNESTHYQILLTSFPHMENHSCFEHMHHIPAPRPEEFHQRSNVTLTLRNLKGCCRHQVQIQPFFSSCLNDCLRHSATVSCPEMPDTPEPIPDYMPLW
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蛋白长度
Extracellular Domain
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分子量
60-70 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IL-17RA (Interleukin-17 receptor A) is a critical component of the IL-17 signaling pathway, which plays a significant role in immune responses, particularly in the context of autoimmune diseases and inflammatory conditions. The IL-17 family consists of several cytokines, with IL-17A being the most studied, known for its pro-inflammatory properties and its involvement in the pathogenesis of various diseases such as rheumatoid arthritis, psoriasis, and multiple sclerosis. The receptor IL-17RA is crucial for mediating the effects of IL-17A and is also involved in the signaling of other IL-17 family members. Research on IL-17RA recombinant proteins has gained momentum due to their potential therapeutic applications. These proteins can be utilized to block the interaction between IL-17 and its receptor, thereby mitigating inflammatory responses in disease models. Furthermore, the exploration of IL-17RA as a drug target has opened new avenues for developing biologics that can provide relief in conditions driven by IL-17 mediated pathways. As scientists continue to unravel the complexities of the immune system, IL-17RA and its associated pathways remain a promising focus for innovative treatments aimed at improving the quality of life for patients suffering from chronic inflammatory diseases. This research not only enhances our understanding of IL-17 signaling but also paves the way for future therapeutic strategies that could lead to the development of effective interventions targeting IL-17RA and its downstream effects in various pathologies.
