Analytical Data
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Gene name
FGFR-3 beta (IIIc)
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简介
The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 beta (IIIc) Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FGFR-3 beta IIIc protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
- Application
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Alternative Names
ACH; CD333; CEK; CEK2; EC 2.7.10; FGF R3; FGFR3; HSFGFR3EX; JTK4
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Species
Human
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Source
HEK293
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Tag
C-Avi;C-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P22607-1
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Expression Region
D127-G375
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Protein Length
Partial
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Molecular Weight
50-60 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Fibroblast growth factor receptor 3 (FGFR3) is a crucial receptor involved in various cellular processes, including proliferation, differentiation, and apoptosis. Of particular interest is the β-isoform, also known as FGFR3b (IIIc), which plays a significant role in skeletal development and homeostasis. Mutations in the FGFR3 gene are associated with various skeletal disorders, such as achondroplasia, a common form of dwarfism. Research into FGFR3b has gained momentum as scientists seek to understand the molecular mechanisms underlying these conditions and develop targeted therapies. The recombinant FGFR3b protein allows for in-depth studies of its structure, function, and interaction with ligands, facilitating insights into its signaling pathways and their alterations in disease states. Such studies have the potential to inform therapeutic approaches that can modulate FGFR3 activity, offering hope for treatments for skeletal dysplasias and related conditions. By elucidating the role of FGFR3b in cellular and developmental biology, researchers aim to pave the way for innovative interventions that can mitigate the effects of FGFR3-related disorders.
