Analytical Data
-
Gene name
FGFR-3 beta (IIIb)
-
简介
The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 beta (IIIb) Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FGFR-3 beta, expressed by HEK293 , with C-Avi, C-His labeled tag.
- Application
-
Alternative Names
ACH; CD333; CEK; CEK2; EC 2.7.10; FGF R3; FGFR3; HSFGFR3EX; JTK4
-
Species
Human
-
Source
HEK293
-
Tag
C-Avi;C-8*His
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P22607-2
-
Expression Region
D127-G377
-
Protein Length
Partial
-
Molecular Weight
40-55 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
FGFR-3 (Fibroblast Growth Factor Receptor 3) is a crucial protein involved in regulating skeletal development and maintenance. Mutations in the FGFR-3 gene are linked to several skeletal dysplasias, including achondroplasia, the most common form of dwarfism. The FGFR-3 beta (IIIb) isoform specifically plays a significant role in the signaling pathways that govern cell proliferation and differentiation. Research on FGFR-3 beta (IIIb) recombinant protein focuses on understanding its structure and function to elucidate the mechanisms underlying its mutations and their resulting phenotypes. By employing molecular biology techniques, such as expression and purification of this isoform, scientists aim to develop therapeutic strategies that target FGFR-3 mediated pathways. Furthermore, studying FGFR-3 beta (IIIb) can provide insight into potential treatments for related skeletal disorders and cancer, where aberrant FGFR signaling is often implicated. Thus, the investigation of FGFR-3 beta (IIIb) recombinant protein is vital in advancing our knowledge of skeletal health and diseases, presenting opportunities for innovative therapeutic approaches.
