Analytical Data
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基因名
FGFR-3 beta (IIIb)
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简介
The FGFR-3 protein is a tyrosine-protein kinase receptor for fibroblast growth factor that is critical for cellular processes, particularly in chondrocytes, osteoblasts, and inner ear development. Its effects span normal skeletal development and postnatal bone mineralization. FGFR-3 beta (IIIb) Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived FGFR-3 beta, expressed by HEK293 , with C-Avi, C-His labeled tag.
- Application
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别名
ACH; CD333; CEK; CEK2; EC 2.7.10; FGF R3; FGFR3; HSFGFR3EX; JTK4
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种属
Human
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表达系统
HEK293
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标签
C-Avi;C-8*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P22607-2
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表达区间
D127-G377
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蛋白长度
Partial
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分子量
40-55 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FGFR-3 (Fibroblast Growth Factor Receptor 3) is a crucial protein involved in regulating skeletal development and maintenance. Mutations in the FGFR-3 gene are linked to several skeletal dysplasias, including achondroplasia, the most common form of dwarfism. The FGFR-3 beta (IIIb) isoform specifically plays a significant role in the signaling pathways that govern cell proliferation and differentiation. Research on FGFR-3 beta (IIIb) recombinant protein focuses on understanding its structure and function to elucidate the mechanisms underlying its mutations and their resulting phenotypes. By employing molecular biology techniques, such as expression and purification of this isoform, scientists aim to develop therapeutic strategies that target FGFR-3 mediated pathways. Furthermore, studying FGFR-3 beta (IIIb) can provide insight into potential treatments for related skeletal disorders and cancer, where aberrant FGFR signaling is often implicated. Thus, the investigation of FGFR-3 beta (IIIb) recombinant protein is vital in advancing our knowledge of skeletal health and diseases, presenting opportunities for innovative therapeutic approaches.
