Analytical Data
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Gene name
LRP-1 Cluster IV
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简介
LRP-1 Cluster IV Protein is involved in endocytosis and phagocytosis of apoptotic cells. The LRP-1 Cluster IV Protein also serves as a receptor for Pseudomonas aeruginosa exotoxin A during microbial infection. LRP-1 Cluster IV Protein, Human (CHO, His) is the recombinant human-derived LRP-1 Cluster IV protein, expressed by CHO , with C-10*His labeled tag.
- Application
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Alternative Names
LRP1 Cluster IV; LRP-1 Cluster IV
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Species
Human
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Source
CHO
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Tag
C-10*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q07954-1
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Expression Region
S3332-D3779
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Protein Length
Partial
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Molecular Weight
60-88 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LRP-1 (Low-Density Lipoprotein Receptor-Related Protein 1) is a key receptor involved in various physiological processes, including lipid metabolism, cell signaling, and the clearance of extracellular matrix components. Cluster IV of LRP-1 specifically refers to a group of receptor variants that play crucial roles in neurological health and disease, particularly in the context of neurodegenerative disorders such as Alzheimer's disease. The study of LRP-1 Cluster IV recombinant proteins is pivotal as it helps elucidate the receptor’s functional domains and mechanisms of action. Researchers are particularly interested in understanding how these variations influence the receptor's ability to bind ligands (such as apolipoproteins and proteases) and mediate cellular uptake, which could reveal new therapeutic targets. Additionally, investigating the structural and functional characteristics of LRP-1 Cluster IV helps in deciphering its role in synaptic plasticity and neuronal survival, contributing to the overall understanding of brain health. Recombinant protein studies allow for detailed exploration of this receptor's interaction with other cellular pathways, providing insights that could lead to novel interventions in treating diseases characterized by dysfunctional lipid metabolism or impaired neuronal function. The findings from this research may also contribute to the development of biomarkers for early diagnosis and prognosis in neurodegenerative conditions. Thus, LRP-1 Cluster IV recombinant proteins represent an important avenue of research with potential implications for therapeutic strategies in brain-related diseases.
