Analytical Data
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基因名
MUC5AC
- Application
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别名
MUC5AC；MUC5；Mucin-5AC
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P98088
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表达区间
5528 to 5627
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氨基酸序列
NQSTCAVYHRSLIIQQQGCSSSEPVRLAYCRGNCGDSSSMYSLEGNTVEH RCQCCQELRTSLRNVTLHCTDGSSRAFSYTEVEECGCMGRRCPAPGDTQH
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MUC5AC is a major gel-forming mucin predominantly expressed in the respiratory and gastrointestinal tracts, playing a crucial role in mucosal barrier function and protection against pathogens. The study of MUC5AC recombinant protein has gained significant attention due to its implications in various diseases, particularly in chronic respiratory conditions such as asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis, where abnormal mucin overproduction leads to mucus hypersecretion and impaired airway function. Understanding the structure and function of MUC5AC is essential for developing therapeutic strategies to regulate mucus production and improve disease outcomes. Recent advances in recombinant protein technology have enabled the production of MUC5AC in a controlled manner, facilitating detailed studies on its biochemical properties, interactions with pathogens, and role in the immune response. By investigating MUC5AC’s properties, researchers aim to uncover its potential as a biomarker for disease progression and treatment response, as well as to explore its therapeutic applications in mucosal diseases. Overall, the exploration of MUC5AC recombinant protein is a promising avenue for enhancing our understanding of mucosal biology and developing innovative interventions for related diseases.
