Analytical Data
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Gene name
PTGIR
- Application
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Alternative Names
PTGIR；PRIPR；Prostacyclin receptor
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P43119
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Expression Region
1-386aa
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AA Sequence
MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPLPPTQQSSGSAVGTSSKAEASVACSLC
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Molecular Weight
40.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PTGIR (Prostacyclin Receptor) is a G protein-coupled receptor that plays a crucial role in various physiological processes, including vasodilation and platelet aggregation inhibition. The receptor is primarily activated by prostacyclin, a potent vasodilator and anti-aggregatory molecule derived from arachidonic acid. Research into PTGIR has gained significant attention due to its implications in cardiovascular health, inflammation, and potential therapeutic targets for diseases such as pulmonary hypertension and cardiovascular disorders. The interest in PTGIR is also fueled by its involvement in mediating the protective effects of prostacyclin on the vascular system. Recombinant PTGIR proteins are crucial for understanding receptor function, signaling pathways, and interactions with ligands and downstream effectors. These studies enable the characterization of receptor pharmacology, contributing to drug discovery and the development of new therapeutic agents. Researchers aim to elucidate the structural and functional dynamics of PTGIR to better comprehend its role in health and disease, ultimately paving the way for innovative treatments that harness its biological effects.
