Analytical Data
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基因名
RNF39
- Application
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别名
RNF39；HZFW；RING finger Protein 39
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H2S5
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表达区间
1-420aa
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氨基酸序列
MWWRDLTRLR LWLKREAIPG EGRKAAKVNA GVGEKGIYTA SSRGGPPSAR SKAVTVVAEG AASRSWLSMD APELGPGLVE RLEQLATCPL CGGSFEDPVL LACEHSFCRA CLARRWGTPP ATGTEASPTA CPCCGLPCPR RSLRSNVRLA VEVRISRELR EKLAEPGARA GRRRGGRIPT MGCLDLPGED MRKTWRRFEV PTSKSSNSED DLPEDYPVVK KMLHRLTADL TLDPGTAHRR LLISADRRSV QLAPPGTPAP PDGPKRFDQL PAVLGAQGFG AGRHCWEVET ADAASCRDSS GEDADDEESH YAVGAAGESV QRKGCVRLCP AGAVWAVEGR GGRLWALTAP EPTLLGGVEP PPRRIRVDLD WERGRVAFYD GRSLDLLYAF QAPGPLGERI FPLFCTCDPR APLRIVPAES
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RNF39, also known as a RING finger protein, has garnered significant interest in the field of molecular biology due to its potential roles in various cellular processes, including protein ubiquitination, DNA damage response, and regulation of gene expression. The protein is characterized by the presence of a RING finger domain, which is integral to its function as an E3 ubiquitin ligase, catalyzing the transfer of ubiquitin moieties to target proteins and thereby marking them for proteasomal degradation. Recent studies have suggested that RNF39 may be involved in the development of several diseases, including cancer, by modulating critical pathways related to cell cycle regulation and apoptosis. Additionally, its intricate involvement in post-translational modifications underscores the necessity for a deeper understanding of its mechanism of action. By generating recombinant RNF39 protein, researchers aim to elucidate its structure-function relationship and pave the way for potential therapeutic interventions that could disrupt its pathological roles in disease. Furthermore, exploring the interactions between RNF39 and its substrates could provide insights into novel regulatory networks, enhancing the understanding of cellular homeostasis and the implications of dysregulated ubiquitination in human health.
