Analytical Data
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基因名
ADNP
- Application
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别名
ADNP；ADNP1；KIAA0784；Activity-dependent neuroprotector homeobox Protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H2P0
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表达区间
全长
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氨基酸序列
full
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ADNP (Activity-Dependent Neuroprotective Protein) is a crucial protein implicated in neurodevelopment and neuroprotection, garnering attention for its role in various neurological disorders. Initially identified as a transcription factor that regulates gene expression in response to neuronal activity, ADNP is found to be involved in critical processes such as synaptic plasticity, neuronal survival, and cognitive function. Research has demonstrated that mutations in the ADNP gene can lead to neurodevelopmental disorders, including intellectual disabilities and autism spectrum disorders, highlighting its significance in brain health. Additionally, ADNP has been linked to the regulation of tau phosphorylation, suggesting a potential connection to neurodegenerative diseases such as Alzheimer's. Studies exploring the functions of ADNP have uncovered its role in promoting neuronal differentiation and survival under stress conditions, further emphasizing its therapeutic potential. The development of ADNP recombinant proteins for research purposes aims to elucidate the intricate mechanisms by which ADNP exerts its neuroprotective effects, paving the way for innovative interventions in treating and preventing neurological disorders. As the field of neuroscience continues to advance, ADNP stands out as a promising target for future research, with the potential to revolutionize our understanding of brain development and disease.
