Analytical Data
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Gene name
MB21D1
- Application
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Alternative Names
MB21D1；C6orf150；MB21D1；Cyclic GMP-AMP synthase
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8N884
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Expression Region
161-522aa
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AA Sequence
GASKLRAVLEKLKLSRDDISTAAGMVKGVVDHLLLRLKCDSAFRGVGLLNTGSYYEHVKISAPNEFDVMFKLEVPRIQLEEYSNTRAYYFVKFKRNPKENPLSQFLEGEILSASKMLSKFRKIIKEEINDIKDTDVIMKRKRGGSPAVTLLISEKISVDITLALESKSSWPASTQEGLRIQNWLSAKVRKQLRLKPFYLVPKHAKEGNGFQEETWRLSFSHIEKEILNNHGKSKTCCENKEEKCCRKDCLKLMKYLLEQLKERFKDKKHLDKFSSYHVKTAFFHVCTQNPQDSQWDRKDLGLCFDNCVTYFLQCLRTEKLENYFIPEFNLFSSNLIDKRSKEFLTKQIEYERNNEFPVFDEF
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Molecular Weight
58.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MB21D1, also known as MBD5 or MYB binding protein 1, is a recently identified member of the MB (methyl-CpG-binding) domain family, implicated in various cellular processes, including DNA damage response and epigenetic regulation. Research on MB21D1 has gained significant attention due to its potential roles in maintaining genome stability and its association with several diseases, including cancer and neurological disorders. The protein's ability to bind methylated DNA suggests it plays a crucial role in gene regulation and chromatin remodeling. Furthermore, mutations and dysregulation of MB21D1 have been linked to developmental issues and various pathologies, prompting further investigation into its functional mechanisms. Given the increasing complexity of gene regulation and the impact of epigenetic modifications on cellular behavior, understanding MB21D1's structure and function can provide valuable insights into its role in health and disease. Recent studies have focused on the characterization of MB21D1 through recombinant protein expression techniques, allowing researchers to explore its biochemical properties, binding affinities, and interactions with other cellular factors. As research progresses, the elucidation of MB21D1's role in cellular processes could uncover novel therapeutic targets for treating disorders associated with its dysregulation, highlighting the importance of this protein in modern molecular biology and medicine.
