Analytical Data
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Gene name
UBXD5
- Application
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Alternative Names
UBX domain-containing Protein 11. Colorectal tumor-associated antigen COA-1. Socius. UBX domain-containing Protein 5
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q5T124
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Expression Region
1-512 aa
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AA Sequence
MSSPLASLSKTRKVPLPSEPMNPGRRGIRIYGDEDEVDMLSDGCGSEEKISVPSCYGGIGAPVSRQVPASHDSELMAFMTRKLWDLEQQVKAQTDEILSKDQKIAALEDLVQTLRPHPAEATLQRQEELETMCVQLQRQVREMERFLSDYGLQWVGEPMDQEDSESKTVSEHGERDWMTAKKFWKPGDSLAPPEVDFDRLLASLQDLSELVVEGDTQVTPVPGGARLRTLEPIPLKLYRNGIMMFDGPFQPFYDPSTQRCLRDILGGFFPSELQRLYPNGVPFKVSDLRNQVYLEDGLDPFPGEGRVVGRQRMHKALDRVEEHPGSRMTAEKFLNRLPKFVIRQGEVIDIRGPIRDTLQNCCPLPARIQEIVVETPTLAAERERSQESPNTPAPPLSMLRIKSENGEQAFLLMMQPDNTIGDVRALLAQARVMDASAFEIFSTFPPTLYQDDTLTLQAAGLVPKAALLLRARRAPKSSLKFSPGPCPGPGPGPSPGPGPGSSPCPGPSPSPQ
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Molecular Weight
83.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UBXD5, also known as ubiquitin regulatory X domain-containing protein 5, plays a crucial role in cellular processes by regulating the ubiquitin-proteasome pathway, which is essential for protein degradation, quality control, and cellular signaling. This protein is particularly interesting due to its interaction with the proteasome and various ubiquitin-conjugating enzymes, which facilitates the recognition and ubiquitination of substrates destined for degradation. Recent research has highlighted its potential involvement in several diseases, including cancer and neurodegenerative disorders, as abnormalities in protein degradation mechanisms are often linked to tumorigenesis and the accumulation of misfolded proteins. Moreover, UBXD5 is implicated in regulating cellular responses to stress and maintaining proteostasis, further emphasizing its biological significance. Understanding the structural and functional characteristics of UBXD5 may provide insights into its mechanism of action and its role in health and disease. Consequently, the study of UBXD5 recombinant protein not only contributes to a deeper understanding of protein homeostasis but also holds promise for the development of novel therapeutic strategies targeting the ubiquitin-proteasome system. This makes UBXD5 an attractive target for further investigation in both basic research and pharmacological applications.
