Analytical Data
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Gene name
SPRED2
- Application
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Alternative Names
SPRED2；Sprouty-related. EVH1 domain-containing Protein 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q7Z698
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Expression Region
1-418aa
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AA Sequence
MTEETHPDDD SYIVRVKAVV MTRDDSSGGW FPQEGGGISR VGVCKVMHPE GNGRSGFLIH GERQKDKLVV LECYVRKDLV YTKANPTFHH WKVDNRKFGL TFQSPADARA FDRGVRKAIE DLIEGSTTSS STIHNEAELG DDDVFTTATD SSSNSSQKRE QPTRTISSPT SCEHRRIYTL GHLHDSYPTD HYHLDQPMPR PYRQVSFPDD DEEIVRINPR EKIWMTGYED YRHAPVRGKY PDPSEDADSS YVRFAKGEVP KHDYNYPYVD SSDFGLGEDP KGRGGSVIKT QPSRGKSRRR KEDGERSRCV YCRDMFNHEE NRRGHCQDAP DSVRTCIRRV SCMWCADSML YHCMSDPEGD YTDPCSCDTS DEKFCLRWMA LIALSFLAPC MCCYLPLRAC YHCGVMCRCC GGKHKAAA
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SPRED2 (Sprouty-related EVH1 domain-containing protein 2) is a member of the Sprouty protein family, which plays a crucial role in modulating receptor signaling pathways, particularly in regulating the Ras-MAPK cascade. This protein is implicated in various biological processes, including cell proliferation, differentiation, and apoptosis. Dysregulation of SPRED2 has been linked to several diseases, including certain types of cancer, making it a significant focus of research. The study of SPRED2 recombinant proteins allows researchers to investigate its molecular interactions and functional mechanisms in detail, providing insights into its role in cellular signaling pathways. By generating and analyzing SPRED2 recombinant proteins, scientists aim to elucidate how SPRED2 exerts its effects on Ras signaling and its potential as a therapeutic target. Furthermore, understanding the structural and functional properties of SPRED2 can pave the way for developing novel strategies to modulate its activity in pathological conditions, enhancing our knowledge of cancer biology and opening avenues for targeted interventions. This research holds promise for advancing our understanding of the intricate regulatory networks governing cell signaling and contributes to the broader field of molecular biology and therapeutic development.
