Analytical Data
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基因名
FBXO15
- Application
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别名
FBXO15; FBX15; F-box only protein 15
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8NCQ5
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表达区间
1-434aa
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氨基酸序列
MPSEILLKIFSYLDAVSLLCTGCVSRRFYHLANDNFIWIGIYSTAFSPARSNWKFNSVEKIAMSMSFLSVQDKEAGYWKKEYITKQIASVKAALADILKPVNPYTGLPVKTKEALRIFGLGWAIILKEKGGKEYIMEHVDLSINDTSVTVIWYGKKWPCLASLSTLDLCGMTPVFTDWYKTPTKHRLRWHSLIAKYNLSHLTISTMIGCDRLIRIFCLHPGLLVGVWKKEEELAFVMANLHFHHLVERSTLGSATIPYELPPHSPFLDDSPEYGLHGYQLHVDLHSGGVFYLCGTFRNLFTKRGNIENGHVKLIVIHLKNNREHLPLIGKVGLSWKTDIFDGCIKSCSMMDVTLLDEHGKPFWCFSSPVCLRSPATPSDSSSFLGQTYNVDYVDAEGRVHVELVWIRETEEYLIVNLVLYLSIAKINHWFGTEY
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分子量
75.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FBXO15, a member of the F-box protein family, is primarily involved in the ubiquitin-proteasome system, which plays a crucial role in regulating protein degradation and cellular processes. It is characterized by the presence of an F-box motif, enabling it to selectively bind to specific substrates for degradation. Research into FBXO15 has gained momentum due to its potential implications in various biological processes, including cell cycle regulation, differentiation, and apoptosis. Abnormal expression or mutations in FBXO15 have been linked to several pathological conditions, including cancer and other diseases. Furthermore, FBXO15's interaction with multiple signaling pathways highlights its significance as a regulatory factor in cellular homeostasis. Understanding the molecular mechanisms by which FBXO15 functions could provide insights into its role in tumorigenesis and its potential as a therapeutic target. Recent studies have also suggested that FBXO15 may influence stem cell pluripotency and differentiation, adding another layer of complexity to its biological significance. Overall, the investigation of FBXO15 and its associated pathways holds promise for the development of novel strategies in disease treatment and understanding fundamental cellular mechanisms.
