Analytical Data
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Gene name
FBXO15
- Application
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Alternative Names
FBXO15; FBX15; F-box only protein 15
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8NCQ5
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Expression Region
1-434aa
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AA Sequence
MPSEILLKIFSYLDAVSLLCTGCVSRRFYHLANDNFIWIGIYSTAFSPARSNWKFNSVEKIAMSMSFLSVQDKEAGYWKKEYITKQIASVKAALADILKPVNPYTGLPVKTKEALRIFGLGWAIILKEKGGKEYIMEHVDLSINDTSVTVIWYGKKWPCLASLSTLDLCGMTPVFTDWYKTPTKHRLRWHSLIAKYNLSHLTISTMIGCDRLIRIFCLHPGLLVGVWKKEEELAFVMANLHFHHLVERSTLGSATIPYELPPHSPFLDDSPEYGLHGYQLHVDLHSGGVFYLCGTFRNLFTKRGNIENGHVKLIVIHLKNNREHLPLIGKVGLSWKTDIFDGCIKSCSMMDVTLLDEHGKPFWCFSSPVCLRSPATPSDSSSFLGQTYNVDYVDAEGRVHVELVWIRETEEYLIVNLVLYLSIAKINHWFGTEY
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Molecular Weight
75.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
FBXO15, a member of the F-box protein family, is primarily involved in the ubiquitin-proteasome system, which plays a crucial role in regulating protein degradation and cellular processes. It is characterized by the presence of an F-box motif, enabling it to selectively bind to specific substrates for degradation. Research into FBXO15 has gained momentum due to its potential implications in various biological processes, including cell cycle regulation, differentiation, and apoptosis. Abnormal expression or mutations in FBXO15 have been linked to several pathological conditions, including cancer and other diseases. Furthermore, FBXO15's interaction with multiple signaling pathways highlights its significance as a regulatory factor in cellular homeostasis. Understanding the molecular mechanisms by which FBXO15 functions could provide insights into its role in tumorigenesis and its potential as a therapeutic target. Recent studies have also suggested that FBXO15 may influence stem cell pluripotency and differentiation, adding another layer of complexity to its biological significance. Overall, the investigation of FBXO15 and its associated pathways holds promise for the development of novel strategies in disease treatment and understanding fundamental cellular mechanisms.
